The Skeleton Twins, starring Bill Hader and Kristen Wiig as estranged siblings, hit theaters this weekend and we got a chance to talk to the SNL-alums about working together on something a little more serious while still managing to make the funniest movie about depressing topics that you could imagine.

A film about love, family and life, The Skeleton Twins is a powerful slice-of-life film anchored by really sweet and touching performances by Hader, Wiig and Luke Wilson.

The Skeleton Twins, co-written and directed by Craig Johnson, co-written by Mark Heyman, and starring Bill Hader, Kristen Wiig, Luke Wilson and Ty Burrell, is in select theaters now.